Who would you like to attack today?: "MessageLabs predicts that Trojans and other malicious code specifically developed to compromise particular organisations will become a greater threat next year. Mark Sunner, chief technology officer, said the singling out of certain companies to be the victim of phishing attacks 'could signal the beginning of a wider trend. Already particular businesses are threatened and blackmailed, indicating a shift from the random, scattergun approach, to customised attacks designed to take advantage of the perceived weaknesses of some businesses.'"—The Register

Zero-hour defenses will become, if they're not already, absolutely required.